Thyreostat II
Thyreostat II - General Information
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Pharmacology of Thyreostat II
Thyreostat II is a thiourea antithyroid agent. Grave's disease is the most common cause of hyperthyroidism. It is an autoimmune disease where an individual's own antibodies attach to thyroid stimulating hormone receptors within cells of the thyroid gland and then trigger overproduction of thyroid hormone. The two thyroid hormones manufactured by the thyroid gland, thyroxine (T4) and triiodothyronine (T3), are formed by combining iodine and a protein called thyroglobulin with the assistance of an enzyme called peroxidase. PTU inhibits iodine and peroxidase from their normal interactions with thyroglobulin to form T4 and T3. This action decreases thyroid hormone production. PTU also interferes with the conversion of T4 to T3, and, since T3 is more potent than T4, this also reduces the activity of thyroid hormones. The actions and use of propylthiouracil are similar to those of methimazole.
Thyreostat II for patients
Take this medicine exactly as directed by your doctor. You may be told to take a higher dose to start, then reduce as your thyroid levels become normal, but your doctor will work out the best dose for you. Propylthiouracil should be taken with a glass of water. The total daily dose may be taken in divided doses over the day or as a single daily dose. Try to get into the habit of taking this medicine at the same times each day to avoid missing any doses. If you forget to take a dose, take it as soon as you remember. Do not take two doses together. If it is almost time to take the next dose, wait until then and then carry on as before. Treatment with propylthiouracil may continue for up to two years. If you suspect that you or someone else has taken an overdose of propylthiouracil contact your doctor or go to the accident and emergency department of your local hospital at once. Always take the container with you if possible, even if it is empty. This medicine is for you. Never give it to others even if their condition appears to be the same as yours.
Thyreostat II Interactions
May increase the effect of oral blood thinners, for example warfarin (Coumadin). Therefore, warfarin dose changes and monitoring for the effects of warfarin on blood clotting are necessary.
Thyreostat II Contraindications
Contraindicated in patients with kidney failure or liver disease.
Additional information about Thyreostat II
Thyreostat II Indication: Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease).
Mechanism Of Action: Thyreostat II binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin (Tg) is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones.
Drug Interactions: Anisindione The anti-thyroid agent causes variations in the anticoagulant effect
Acenocoumarol The anti-thyroid agent causes variations in the anticoagulant effect
Dicumarol The anti-thyroid agent causes variations in the anticoagulant effect
Warfarin The anti-thyroid agent causes variations in the anticoagulant effect
Digoxin The anti-thyroid agent increases the effect of digoxin
Food Interactions: Take at the same time everyday.
Generic Name: Propylthiouracil
Synonyms: Propilthiouracil; Propyl-Thyracil; Propyl-Thiorit; Propyl-Thiorist; Propythiouracil; PTU; Procasil; Propacil; Thiuragyl; Protiural; Prothyran; Prothycil; Prothiurone; Prothiucil; Propylthiorit; Propycil
Drug Category: Antithyroid Agents; Antimetabolites
Drug Type: Small Molecule; Approved
Other Brand Names containing Propylthiouracil: Thyreostat II;
Absorption: Well absorbed following oral administration.
Toxicity (Overdose): Oral, rat: LD50 = 1250 mg/kg.
Protein Binding: 82%
Biotransformation: Not Available
Half Life: 2 hours
Dosage Forms of Thyreostat II: Tablet Oral
Chemical IUPAC Name: 6-propyl-2-sulfanylidene-1H-pyrimidin-4-one
Chemical Formula: C7H10N2OS
Propylthiouracil on Wikipedia: https://en.wikipedia.org/wiki/Propylthiouracil
Organisms Affected: Humans and other mammals